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12 Buspirone Interactions You Should Know About
Feb 27, 2025
Buspirone can be a helpful medication for relieving symptoms of anxiety, but it does interact with other drugs and supplements. These interactions can cause a number of complications–ranging from serious side effects to potentially reducing how well the drug works. If you've been prescribed buspirone, it's important to know certain interactions that can affect the safety or effectiveness of your buspirone or other drugs.
Drugs That Interact With Buspirone
The chart below lists some, but not all, of the interactions that can occur with buspirone.
Buspirone Interactions
Type of Drug or InteractionExamplesRisk of Combined Use
AntidepressantsProzac (fluoxetine), Cymbalta (duloxetine), amitriptylineIncreased risk of serotonin syndrome
Monoamine oxidase inhibitors (MAOIs)Nardil (phenelzine), Zyvox (linezolid)Increased risk of serotonin syndrome, high blood pressure
Other drugs that can increase serotonin levelsImitrex (sumatriptan), Adderall (amphetamine salts)Increased risk of serotonin syndrome
CNS depressantsAlcohol, oxycodone, Sonata (zaleplon)Increased risk of central nervous system depression
Calcium channel blockersCardizem (diltiazem), Verelan (verapamil)Increased risk of buspirone side effects
Anti-seizure drugsDilantin (phenytoin), phenobarbital, Tegretol (carbamazepine)May cause reduced effectiveness of buspirone
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